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Low testosterone in women and brain health

Updated: Mar 8


Low testosterone levels have been associated with cognitive decline, particularly in older men. Testosterone is a hormone that plays a role in various bodily functions, including brain health and cognitive function. While the exact mechanisms are not fully understood, there are several ways in which low testosterone may contribute to cognitive decline:

1. Brain structure and connectivity: Testosterone has a protective effect on brain cells and can promote the growth and maintenance of neural connections. Low testosterone levels may lead to decreased brain volume, particularly in areas associated with memory and cognition.

2. Neurotransmitter activity: Testosterone influences the activity of neurotransmitters, such as serotonin, dopamine, and norepinephrine, which are involved in mood regulation and cognitive processes. Low testosterone levels can disrupt the balance of these neurotransmitters, potentially affecting cognition.

3. Neuroinflammation: Testosterone has anti-inflammatory properties and can help reduce neuroinflammation in the brain. Chronic inflammation in the brain has been linked to cognitive decline and neurodegenerative diseases. Low testosterone levels may contribute to increased inflammation, which can negatively impact cognitive function.

4. Vascular health: Testosterone plays a role in maintaining healthy blood vessels. Reduced testosterone levels can contribute to vascular problems, such as decreased blood flow to the brain. Impaired blood flow and vascular health have been associated with cognitive impairment.

5. Mood and motivation: Testosterone can influence mood and motivation, and low levels of testosterone may lead to symptoms such as depression, fatigue, and reduced motivation. These factors can indirectly impact cognitive function and overall mental performance.

Please note, while low testosterone levels may be a contributing factor to cognitive decline, they are not the sole cause. Other factors, such as age, genetics, overall health, and lifestyle factors, can also influence cognitive function. If you have concerns about cognitive decline or low testosterone levels, it is advisable to consult a healthcare professional who can provide a comprehensive evaluation and guide you in appropriate management options.

Dr Purity Carr is a GP and Menopause Doctor in Harvey, Western Australia
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